Human Brain Organoids as an In Vitro Model System of Viral Infectious Diseases

Frontiers in Immunology

Aihua Liu¹  Peng Yue¹  Wenjing Cao¹  Jing Kong¹  Jingjing Chen¹  Fukai Bao²  Meixiao Liu²  Yu Zhang²  Yuxin Fan²  Xin Xu²  Xuan Su³ 

[1] Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China;Department of Microbiology and Immunology, Kunming Medical University, Kunming, China;Department of Pediatrics, The Affiliated Children Hospital, Kunming Medical University, Kunming, China;Yunnan Province Key Laboratory for Tropical Infectious Diseases in Universities, Kunming Medical University, Kunming, China;

关键词: brain organoid;    brainoid;    infection;    virus;    prion;    model system;   

DOI  :  10.3389/fimmu.2021.792316

来源: DOAJ

【 摘 要 】

Brain organoids, or brainoids, have shown great promise in the study of central nervous system (CNS) infection. Modeling Zika virus (ZIKV) infection in brain organoids may help elucidate the relationship between ZIKV infection and microcephaly. Brain organoids have been used to study the pathogenesis of SARS-CoV-2, human immunodeficiency virus (HIV), HSV-1, and other viral infections of the CNS. In this review, we summarize the advances in the development of viral infection models in brain organoids and their potential application for exploring mechanisms of viral infections of the CNS and in new drug development. The existing limitations are further discussed and the prospects for the development and application of brain organs are prospected.

【 授权许可】

Unknown