The Impact of Patient Characteristics and Tumor Biology on the Accuracy of Preoperative Staging of Colon Cancer in Denmark. A Nationwide Cohort Study

Cancers

Malene Roland V. Pedersen¹  Søren Rafael Rafaelsen¹  Jan Lindebjerg²  Hans Bjarke Rahr²  Torben Frøstrup Hansen² 

[1] Department of Radiology, Vejle Hospital, University Hospital of Southern Denmark, DK-7100 Vejle, Denmark;Department of Regional Health Research, University of Southern Denmark, DK-7100 Vejle, Denmark;

关键词: mismatch repair;    colon cancer;    registry study;    tumor staging;   

DOI  :  10.3390/cancers13174384

来源: DOAJ

【 摘 要 】

Background: Colon cancer is a common disease in western populations. The aim of this study was to assess the impact of mismatch repair (MMR) deficiency and other patient and tumor characteristics on the accuracy of preoperative staging by comparing histopathological T- and N-categories of the resected specimen with the preoperative clinical stage in a nationwide cohort of patients treated for colon cancer by elective bowel resection with curative intent. Methods: A register study of a cohort extracted from the Danish Colorectal Cancer Group (DCCG) database, which holds prospective data on all new cases of colon and rectum cancer in Denmark. Patients diagnosed with colon cancer and treated with an elective bowel resection with curative intent in the years 2016–2019 were analyzed. Results: A total of 6102 patients were included (n = 3161 (52%) men and n = 2941 (48%) women) with a median age of 72 years (range 23–97 years). MMR was deficient in 24% of the patients and proficient in 76%. MMR deficiency, tumor sidedness and histopathological type were significant predictors of the accuracy of preoperative staging of colon cancer in univariate and multivariate analysis. MMR status in particular showed a strong impact on the risk of overstaging. Conclusions: MMR deficiency, but also tumor sidedness and to some degree histopathological type, impacted the accuracy of preoperative staging of colon cancer. MMR status should be taken into consideration in everyday clinical staging.

【 授权许可】

Unknown