A variant of acute promyelocytic leukemia with t(4;17)(q12;q21) showed two different clinical symptoms

Hematology Reports

Yusuke Nishio¹  Koji Tsuta¹  Yoshihiko Kadosaka¹  Yoshiko Azuma²  Akiko Konishi²  Atsushi Satake²  Yukie Tsubokura²  Shosaku Nomura²  Hideaki Yoshimura²  Shinya Fujita²  Kazuyoshi Ishii²  Tomoki Ito²  Ryo Saito²  Takahisa Nakanishi²  Aya Nakaya²  Masaaki Hotta² 

[1] Department of Pathology and Laboratory Medicine, Kansai Medical University, Osaka;First Department of Internal Medicine, Kansai Medical University, Osaka;

关键词: acute promyelocytic leukemia;    t(4;    17)(q12;    q21);    PML-RARA;    all-trans retinoic acid;   

DOI  :  10.4081/hr.2019.7971

来源: DOAJ

【 摘 要 】

A 63-year-old man was diagnosed with a rare variant of acute promyelocytic leukemia (APL) with t(4;17)(q12; q21) that showed atypical morphological features and two different clinical symptoms. He was started on standard induction chemotherapy for acute myeloid leukemia, which decreased myeloblast numbers; however, APL-like blasts remained. He then received a salvage therapy that added all-trans retinoic acid (ATRA). After ATRA commenced, APL-like blasts disappeared and cytogenetic analysis became normal. However, myeloblasts subsequently increased, and he became resistant. In summary, this patient exhibited two different clinical courses of acute myeloid leukemia and APL.

【 授权许可】

Unknown