RNase III, Ribosome Biogenesis and Beyond

Microorganisms

Maxence Lejars¹  Asaki Kobayashi¹  Eliane Hajnsdorf² 

[1] Division of Biomedical Science, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan;Institut de Biologie Physico-Chimique, UMR8261, CNRS, Université de Paris, 75005 Paris, France;

关键词: RNase III;    ribosome biogenesis;    bacteria;    eukaryotes;   

DOI  :  10.3390/microorganisms9122608

来源: DOAJ

【 摘 要 】

The ribosome is the universal catalyst for protein synthesis. Despite extensive studies, the diversity of structures and functions of this ribonucleoprotein is yet to be fully understood. Deciphering the biogenesis of the ribosome in a step-by-step manner revealed that this complexity is achieved through a plethora of effectors involved in the maturation and assembly of ribosomal RNAs and proteins. Conserved from bacteria to eukaryotes, double-stranded specific RNase III enzymes play a large role in the regulation of gene expression and the processing of ribosomal RNAs. In this review, we describe the canonical role of RNase III in the biogenesis of the ribosome comparing conserved and unique features from bacteria to eukaryotes. Furthermore, we report additional roles in ribosome biogenesis re-enforcing the importance of RNase III.

【 授权许可】

Unknown