High Interferon-γ Uniquely in Vδ1 T Cells Correlates with Markers of Inflammation and Axonal Damage in Early Multiple Sclerosis

Frontiers in Immunology

Lenka Novakova²  Clas Malmeström²  Jan Lycke²  Markus Axelsson²  Susanna L. Cardell³  Avadhesh Kumar Singh³  Henrik Zetterberg⁴ 

[1] Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden;Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK;Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden;

关键词: cerebrospinal fluid;    gamma-delta T cells;    interferon-gamma;    multiple sclerosis;    natalizumab;    Vdelta1 T cells;   

DOI  :  10.3389/fimmu.2017.00260

来源: DOAJ

【 摘 要 】

We have identified a population of T lymphocytes in peripheral blood, Vδ1 TCRγδ T lymphocytes, which unexpectedly was uniquely expressing high production of interferon-γ in newly diagnosed, untreated multiple sclerosis (MS) patients. IFN-γ production in this population distinctly correlated to parameters of clinical disease activity, inflammation, and neuronal damage. These Vδ1 T lymphocytes belong to a population of innate T lymphocytes that recognize antigen in the context of CD1d/CD1c and which include reactivity to the myelin glycosphingolipid sulfatide. Importantly, patients treated with natalizumab, blocking leukocyte transmigration to central nervous system, had completely normalized levels of interferon-γ-producing Vδ1 T lymphocytes. A biomarker and early sign of demyelinating disease in MS is much warranted and would help identify immunopathogenesis and prognosis of disease as well as monitor success with adequate treatment. The present study identifies the Vδ1 T lymphocytes as an early marker of MS and a possible link to understanding the disease etiology.

【 授权许可】

Unknown