Nose-to-Brain Delivery

Pharmaceutics

Elisabetta Gavini¹  Paolo Giunchedi¹  MariaCristina Bonferoni² 

[1] Department of Chemistry and Pharmacy, University of Sassari, 07100 Sassari, Italy;Department of Drug Sciences, University of Pavia, 27100 Pavia, Italy;

关键词: nasal route;    brain targeting;    nanocarriers;    nanoemulsions;    penetration enhancers;    transmucosal delivery;   

DOI  :  10.3390/pharmaceutics12020138

来源: DOAJ

【 摘 要 】

Nose-to-brain delivery represents a big challenge. In fact there is a large number of neurological diseases that require therapies in which the drug must reach the brain, avoiding the difficulties due to the blood−brain barrier (BBB) and the problems connected with systemic administration, such as drug bioavailability and side-effects. For these reasons the development of nasal formulations able to deliver the drug directly into the brain is of increasing importance. This Editorial regards the contributions present in the Special Issue “Nose-to-Brain Delivery”.

【 授权许可】

Unknown