Aquaporins in Urinary Extracellular Vesicles (Exosomes)

International Journal of Molecular Sciences

Sayaka Oshikawa¹  Hiroko Sonoda¹  Masahiro Ikeda¹ 

[1] Department of Veterinary Pharmacology, University of Miyazaki, Miyazaki 889-2192, Japan;

关键词: exosomes;    extracellular vesicles;    aquaporin-1;    aquaporin-2;    kidney;    urine;   

DOI  :  10.3390/ijms17060957

来源: DOAJ

【 摘 要 】

Since the successful characterization of urinary extracellular vesicles (uEVs) by Knepper’s group in 2004, these vesicles have been a focus of intense basic and translational research worldwide, with the aim of developing novel biomarkers and therapeutics for renal disease. Along with these studies, there is growing evidence that aquaporins (AQPs), water channel proteins, in uEVs have the potential to be diagnostically useful. In this review, we highlight current knowledge of AQPs in uEVs from their discovery to clinical application.

【 授权许可】

Unknown