The association between socioeconomic disparities and left ventricular hypertrophy in chronic kidney disease: results from the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD)

BMC Nephrology

Soo Wan Kim¹  Hyo Jin Kim²  Wookyung Chung³  Suah Sung⁴  Miyeun Han⁵  Curie Ahn⁶  Eunjeong Kang⁶  Kook-Hwan Oh⁶  Tae-Hyun Yoo⁷  Kyu-Beck Lee⁸  Joongyub Lee⁹ 

[1] Department of Internal Medicine, Chonnam National University Medical School;Department of Internal Medicine, Dongguk University Gyeongju Hospital;Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University School of Medicine;Department of Internal Medicine, Nowon Eulji Medical Center, Eulji University;Department of Internal Medicine, Pusan National University Hospital;Department of Internal Medicine, Seoul National University College of Medicine;Department of Internal Medicine, Yonsei University College of Medicine;Division of Nephrology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine;School of Medicine, Inha University;

关键词: Chronic kidney disease;    Left ventricular hypertrophy;    Education;    Income;    Socioeconomic status;   

DOI  :  10.1186/s12882-018-1005-3

来源: DOAJ

【 摘 要 】

Abstract Background Left ventricular hypertrophy (LVH) is one of the risk factors for cardiovascular (CV) disease and mortality. However, the relationship between socioeconomic status (SES) and LVH in chronic kidney disease remains unclear. Methods Data were collected from the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD, NCT01630486 at http://www.clinicaltrials.gov). Subjects with CKD and aged ≥50 were included. SES was characterized based on monthly income and educational attainment, each of which was divided into three strata. LVH was defined as LV mass/height2.7 ≥ 47 g/m2.7 in female and ≥ 50 g/m2.7 in male. Age, sex, diabetes, CKD stage, body mass index, blood pressure and physical activity were included as covariates. Results A total of 1361 patients were included. Mean age was 60.9 ± 6.9 years, and 63.2% were men. Higher education level was associated with higher monthly income (P for trend < 0.001). The lowest education level was independently associated with LVH (lower than high school, adjusted odds ratio [OR] 1.485, 95% CI 1.069–2.063, P = 0.018; completed high school, adjusted OR 1.150, 95% confidence interval [CI] 0.834–1.584, P = 0.394; highest education level as the reference). Monthly income level was marginally associated with LVH after adjusting for covariates ($1500-4500, adjusted OR 1.230, 95% CI 0.866–1.748, P = 0.247; < $1500, adjusted OR 1.471, 95% CI 1.002–2.158, P = 0.049; > $4500; reference). Conclusions In the CKD population, lower SES, defined by educational attainment and low income level exhibited a significant association with LVH, respectively. Longitudinal follow-up will reveal whether lower SES is associated with poor CKD outcomes.

【 授权许可】

Unknown