From Bench to Bedside in Precision Medicine: Diabetes Mellitus and Peri-Implantitis Clinical Indices with a Short-Term Follow-Up: A Systematic Review and Meta-Analysis

Journal of Personalized Medicine

Salvatore Scacco¹  Vito Crincoli¹  Andrea Ballini¹  Stefania Cantore¹  Riccardo Aiuto²  Francesca Spirito³  Mario Dioguardi³  Diego Sovereto³  Cristian Quarta³  Giuseppe Troiano³  Michele Di Cosola³  Lorenzo Lo Muzio³  Daniele Garcovich⁴  Mario Alovisi⁵  Michele Covelli⁶  Luigi Laino⁷  Annarita Malcangi⁸ 

[1] Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari “Aldo Moro”, 70124 Bari, Italy;Department of Biomedical, Surgical, and Dental Science, University of Milan, 20122 Milan, Italy;Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy;Department of Dentistry, Universidad Europea de Valencia, Paseo de la Alameda 7, 46010 Valencia, Spain;Department of Surgical Sciences, Dental School, University of Turin, 10127 Turin, Italy;Interuniversity Research Center “Population, Environment and Heath”—CIRPAS, University of Bari “Aldo Moro”, 70124 Bari, Italy;Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania “Luigi Vanvitelli”, 80121 Naples, Italy;Public Local Health Company (Azienda Sanitaria Locale, ASL), B.A.T, 76125 Trani, Italy;

关键词: diabetes mellitus;    peri-implantitis;    dental implants;    marginal bone loss;    plaque index;    bleeding on probing;   

DOI  :  10.3390/jpm12020235

来源: DOAJ

【 摘 要 】

Background and objective: Diabetes mellitus (DM) refers to a group of metabolic disorders characterized by hyperglycemia resulting from impaired secretion or action of insulin. The high levels of glucose in the blood can negatively affect the healing processes through alterations in vascularization, bone remodeling, and with increased susceptibility to infections. Diabetes mellitus is therefore a risk factor not only for many systemic diseases, but also for localized problems such as peri-implantitis. The objective of this systematic review was to identify a clear relationship between peri-implant inflammation indices and glycemic levels, through the investigation of prospective studies that report data on a short-term follow-up period. Our hypothesis was that peri-implant inflammatory indices may already present themselves in a statistically significant way as altered in patients with DM compared to patients without DM. Materials and methods: This review was reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA). Results: More than 992 records were identified in the PubMed, Scopus, and Cochrane Central Register of Controlled Trial electronic databases and only seven studies were included in the meta-analysis. The results of the meta-analysis report worse outcomes in patients with DM, even in the short period of six months, for peri-implatitis inflammation indices, such as Marginal bone loss (standardized (Std). mean difference (MD) 12\6 months 0.81 [0.45, 1.17]\1.82 [0.53, 3.10]), Bleeding on probing (Std. MD 12\6 months 2.84 [1.34, 4.34]\3.44 [1.41, 5.50]), Probing depth (Std. MD 12\6 months 1.14 [0.60, 1.68]\2.24 [0.66, 3.83]), and the plaque index (Std. MD 12 months 2.83 [0.09, 5.57]). Conclusion: The literature linking glycaemic control to peri-implant disease is highly heterogeneous due to lack of consistency of the definition of peri-implantitis and its clinical indicators among studies. Therefore, interpretation of finding and relevance to clinical practice should be considered on individual bases. In the era of personalized medicine, the clinician should utilize individualized information from translational researches and analyze all risk factors to provide the patient with evidence-based treatment options.

【 授权许可】

Unknown