Bioactivities and Medicinal Value of Solanesol and Its Accumulation, Extraction Technology, and Determination Methods

Biomolecules

Zhongfeng Zhang¹  Ning Yan¹  Linqing Liu¹  Hongbo Zhang¹  Yanhua Liu¹  Yongmei Du¹  Xinmin Liu¹ 

[1] Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China;

关键词: solanesol;    bioactivity;    medicinal value;    accumulation;    extraction technology;    determination methods;   

DOI  :  10.3390/biom9080334

来源: DOAJ

【 摘 要 】

Solanesol, an aliphatic terpene alcohol composed of nine isoprene units, is mainly found in solanaceous plants. Particularly, tobacco (Nicotiana tabacum), belonging to the Solanaceae family, is the richest plant source of solanesol, and its leaves have been regarded as the ideal material for solanesol extraction. Since the discovery of solanesol in tobacco, significant progress has been achieved in research on solanesol’s bioactivities, medicinal value, accumulation, extraction technology, and determination methods. Solanesol possesses strong free radical absorption ability and antioxidant activity owing to the presence of several non-conjugated double bonds. Notably, solanesol’s anti-inflammatory, neuroprotective, and antimicrobial activities have been previously demonstrated. Solanesol is a key intermediate in the synthesis of coenzyme Q10, vitamin K2, and the anticancer agent synergiser N-solanesyl-N,N′-bis(3,4-dimethoxybenzyl) ethylenediamine. Other applications of solanesol include solanesol derivative micelles for hydrophobic drug delivery, solanesol-derived scaffolds for bioactive peptide multimerization, and solanesol-anchored DNA for mediating vesicle fusion. Solanesol accumulation in plants is influenced by genetic and environmental factors, including biotic stresses caused by pathogen infections, temperature, illumination, and agronomic measures. Seven extraction technologies and seven determination methods of solanesol are also systematically summarized in the present review. This review can serve as a reference for solanesol’s comprehensive application.

【 授权许可】

Unknown