Use of a Si/CdTe Compton Camera for In vivo Real-Time Monitoring of Annihilation Gamma Rays Generated by Carbon Ion Beam Irradiation

Frontiers in Oncology

Raj Kumar Parajuli¹  Takashi Nakano¹  Takahiro Oike²  Shintaro Shiba³  Tatsuya Ohno³  Makoto Sakai³ 

[1] Department of Molecular Imaging and Theranostics, National Institutes for Quantum and Radiological Science and Technology, Inage, Japan;Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Japan;Gunma University Heavy Ion Medical Center, Maebashi, Japan;

关键词: carbon ion beams;    Compton camera;    annihilation gamma-rays;    adaptive therapy;    irradiated site visualization;    activated elements with annihilation gamma-ray transport visualization;   

DOI  :  10.3389/fonc.2020.00635

来源: DOAJ

【 摘 要 】

The application of annihilation gamma-ray monitoring to the adaptive therapy of carbon ion radiotherapy (C-ion RT) requires identification of the peak intensity position and confirmation of activated elements with annihilation gamma-rays generated at the C-ion-irradiated site from those transported to unirradiated sites. Real-time monitoring of C-ion-induced annihilation gamma-rays was implemented using a Compton camera in a mouse model. An adult C57BL/6 mouse was anesthetized, and C-ion beams were directed into the abdomen at 1 × 109 particles/s for 20 s. The 511 keV annihilation gamma-rays, generated by the interaction between the irradiated C-ion beam and the target mouse, were detected using a silicon/cadmium telluride (Si/CdTe) Compton camera for 20 min immediately after irradiation. The irradiated site and the peak intensity position of 511 keV gamma emissions due to C-ion beam irradiation on a mouse were observed at the abdomen of the mouse by developing Compton images. Moreover, the positron emitter transport was observed by evaluating the range of gamma-ray emission after the C-ion beam irradiation on the mouse. Our data suggest that by confirming the peak intensity and beam range of C-ion RT with Si/CdTe-based Compton camera, it would be possible to reduce the intra-fractional and inter-fractional dose distribution degradation. Therefore, the results of this study would contribute to the future development of adaptive therapy with C-ion RT for humans.

【 授权许可】

Unknown