Безопасность и риск фармакотерапии | |
CHONDROTOXICITY OF FLUOROQUINOLONES IN CHILDREN: YES OR NO? | |
A. I. Kamenev1  S. S. Postnikov2  S. Y. Semykin3  V. P. Nazhimov3  | |
[1] Lomonosov Moscow State University;Pirogov Russian National Research Medical University;State Budgetary Healthcare Institution «Russian Children's Clinical Hospital»; | |
关键词: дети; муковисцидоз; апластическая анемия; монофторхинолоны; артротоксичность; линейный рост; морфология хряща; кумуляция фторхинолонов; children; cystic fibrosis; aplastic avemia; monofluoroquinolones; arthrotoxicity; linear growth; chondral morphology; fluoroquinolones accumulation; | |
DOI : | |
来源: DOAJ |
【 摘 要 】
Two groups of children on therapy with monofluoroquinolones were enrolled in this open research trial: 169 patients with cystic fibrosis (exacerbation period) and 55 patients with aplastic anemia (neutropenic phase); age was from 6 months to 16 years. The aim of the study was to compare tolerability (with the focus on arthrotoxicity) of ciprofloxacin, ofloxacin and pefloxacin during intermittent (15-50 mg/kg/day in cystic fibrosis patients) and prolonged continuous therapy (10-15 mg/kg/day in patients with aplastic anemia). Quinolone-induced arthropathy was reported in 7, 6% of all cases, mainly during pefloxacin therapy (31, 8%), and more frequently in patients with aplastic anemia (10, 9% vs. 7, 7%), only in pubertal children, and was fully reversible with no influens on the lineal growth. Following the monofluoroquinolones use, residual joint-related symptoms were not observed because monofluoroquinolones did not achieve chondrotoxic concentrations in cartilaginous structures.
【 授权许可】
Unknown