CHONDROTOXICITY OF FLUOROQUINOLONES IN CHILDREN: YES OR NO?

Безопасность и риск фармакотерапии

A. I. Kamenev¹  S. S. Postnikov²  S. Y. Semykin³  V. P. Nazhimov³ 

[1] Lomonosov Moscow State University;Pirogov Russian National Research Medical University;State Budgetary Healthcare Institution «Russian Children's Clinical Hospital»;

关键词: дети;    муковисцидоз;    апластическая анемия;    монофторхинолоны;    артротоксичность;    линейный рост;    морфология хряща;    кумуляция фторхинолонов;    children;    cystic fibrosis;    aplastic avemia;    monofluoroquinolones;    arthrotoxicity;    linear growth;    chondral morphology;    fluoroquinolones accumulation;   

DOI  :  

来源: DOAJ

【 摘 要 】

Two groups of children on therapy with monofluoroquinolones were enrolled in this open research trial: 169 patients with cystic fibrosis (exacerbation period) and 55 patients with aplastic anemia (neutropenic phase); age was from 6 months to 16 years. The aim of the study was to compare tolerability (with the focus on arthrotoxicity) of ciprofloxacin, ofloxacin and pefloxacin during intermittent (15-50 mg/kg/day in cystic fibrosis patients) and prolonged continuous therapy (10-15 mg/kg/day in patients with aplastic anemia). Quinolone-induced arthropathy was reported in 7, 6% of all cases, mainly during pefloxacin therapy (31, 8%), and more frequently in patients with aplastic anemia (10, 9% vs. 7, 7%), only in pubertal children, and was fully reversible with no influens on the lineal growth. Following the monofluoroquinolones use, residual joint-related symptoms were not observed because monofluoroquinolones did not achieve chondrotoxic concentrations in cartilaginous structures.

【 授权许可】

Unknown