The relationships between FLAIS, a novel insulin sensitivity index, and cardiovascular risk factors in a population-based study

Cardiovascular Diabetology

Anna Szpakowicz¹  Monika Karczewska-Kupczewska²  Irina Kowalska²  Marcin Kondraciuk³  Zofia Stachurska³  Marlena Dubatówka³  Karol Kamiński³  Agnieszka Nikołajuk⁴  Marek Strączkowski⁴ 

[1] Department of Cardiology, Medical University of Białystok;Department of Internal Medicine and Metabolic Diseases, Medical University of Białystok;Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Białystok;Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences;

关键词: Insulin resistance;    Biomarker;    Cardiovascular risk;    Blood pressure;    Lipids;    Waist circumference;   

DOI  :  10.1186/s12933-022-01491-y

来源: DOAJ

【 摘 要 】

Abstract Background Insulin resistance is a risk factor for cardiovascular disease. Recently, we have developed a novel index, FLAIS (Fasting Laboratory Assessment of Insulin Sensitivity), which accurately reflects insulin sensitivity, measured with hyperinsulinemic-euglycemic clamp, in different groups of subjects. The aim of the present study was to assess the relationship of FLAIS with cardiovascular risk factors in a population-based study. Methods The study group comprised 339 individuals from the ongoing Białystok Plus study, without previously known diabetes. Clinical examination, oral glucose tolerance test and the measurement of blood laboratory parameters were performed. Results Prediabetes (impaired fasting glucose and/or impaired glucose tolerance) was diagnosed in 165 individuals whereas type 2 diabetes was diagnosed in 19 subjects. FLAIS was lower in individuals with prediabetes and diabetes in comparison with individuals with normal glucose tolerance. FLAIS was significantly related to waist circumference, systolic and diastolic blood pressure, triglycerides, HDL-cholesterol and LDL-cholesterol in the entire study group and in the subgroups with normal glucose tolerance and with prediabetes/diabetes. HOMA-IR, QUICKI and Matsuda index were not related to blood pressure and LDL-cholesterol in individuals with normal glucose tolerance. Majority of the adjusted models with FLAIS were characterized by better fit with the data in comparison with other indices for all cardiovascular risk factors except waist circumference. Conclusions FLAIS represents useful index to assess the cluster of insulin resistance-associated cardiovascular risk factors in general population.

【 授权许可】

Unknown