Concise Review on Clinical Applications of Conditioned Medium Derived from Human Umbilical Cord-Mesenchymal Stem Cells (UC-MSCs)

International Journal of Hematology-Oncology and Stem Cell Research

Rosa Di Liddo¹  Madhumala Gopinath²  Surajit Pathak²  Ganesan Jothimani²  Sushmitha Sriramulu²  Ramachandran Murugesan²  Antara Banerjee²  Francesco Marotta³ 

[1] Department of Pharmacology and Pharmaceutical Sciences, University of Padova, Padova, Italy;Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Chennai- 603 103, India;ReGenera R&D International for Aging Intervention, Milano-Beijing, Italy-China, VCC Preventive Medical Promotion Foundation, Beijing, China;

关键词: Umbilical cord;    Stem cells;    Conditioned medium;    Therapeutics;    Isolation;   

DOI  :  

来源: DOAJ

【 摘 要 】

In recent years, mesenchymal stem cells have provoked much attentiveness in the field of regenerative medicine because of their differentiation potential and the capability to facilitate tissue repair via the emancipation of biologically active molecules. They have gained interest because of their distinctive curative properties. Mesenchymal stem cells are isolated from the Wharton’s jelly part of umbilical cord possessing higher proliferation capacity, immunomodulatory activity, plasticity, as well as self-renewal capacity than the mesenchymal stem cells from various origins, and it is considered to be the best resource for allogeneic transplantation. The isolated umbilical cord-derived mesenchymal stem cells are cultured in the Dulbecco’s Modified Eagle’s Medium, and thereby it begins to release soluble factors into the medium during the period of culture which is termed as conditioned medium. This conditioned media has both differentiation capacity and therapeutic functions. Thus, it can be able to differentiate the cells into different lineages and the paracrine effect of these cells helps in replacement of the damaged cells. This medium may accord to optimization of diagnostic and prognostic systems as well as the generation of novel and targeted therapeutic perspectives.

【 授权许可】

Unknown