The pro-depressive effect of levodopa in a 6-OHDA-induced hemiparkinsonism rat model

Alʹmanah Kliničeskoj Mediciny

O. V. Abramova¹  V. M. Ushakova²  V. P. Chekhonin²  O. S. Karimova²  Ya. A. Zorkina²  A. Yu. Morozova²  E. A. Zubkov² 

[1] Lomonosov Moscow State University;Serbsky Federal Medical Research Centre for Psychiatry and Narcology;

关键词: neurodegenerative disorders;    parkinson's disease;    6-ohda;    levodopa;   

DOI  :  10.18786/2072-0505-2020-48-005

来源: DOAJ

【 摘 要 】

Rationale: Treatment of Parkinson's disease has been by now symptomatic. The literature on the efficacy and side effects of levodopa has been contradictory. Some authors mention an anti-depressant effect of the agent, while others believe that it is exactly levodopa that eventually induces the occurrence of depressive symptoms. Aim: To reproduce the OHDA-hemiparkinsonism rat model with subsequent assessment of both external and structural manifestations of the disorder, as well as to study the efficacy of levodopa for motor and non-motor symptoms of parkinsonism. Materials and methods: The study was performed in 52 male Wistar rats. The disease model included stereotaxic administration of neurotoxic 6-OHDA into the pars compacta of the substantia nigra. At 2 months after the administration, the animals underwent test for motor (Rotarod, cylinder, ketamine-induced rotation in the rotometer) and non-motor abnormalities (open field, social interest, conditioned escape response). Results: In 18% of the animals no hemiparkinsonism symptoms were found. 32% of rats had only motor symptoms, whereas in 50% of the animals both motor and non-motor symptoms were noted. Levodopa could partially correct the motor abnormalities, with augmentation of depressive-like behavior. Conclusion: Levodopa has shown its partial efficacy in correction of the motor symptoms caused by administration of 6-OHDA neurotoxin; however, it caused such side effects as augmentation of depressive-like behavior and anxiety.

【 授权许可】

Unknown