Transition From Parenteral to Enteral Nutrition and Postnatal Growth in Very Preterm Infants During Their First 28 Days of Life

Frontiers in Pediatrics

Huaiyan Wang¹  Yan Gao²  Shuping Han³  Zhangbin Yu³  Rongrong Chen⁴  Li Gu⁴  Xingxing Lu⁵  Weiwei Hou⁵  Bo Wang⁶  Na Wang⁶  Jia Zhang⁶ 

[1] Department of Neonatology, Changzhou Maternity and Child Health Care Hospital, Changzhou, China;Department of Neonatology, Lianyungang Maternity and Child Health Care Hospital, Lianyungang, China;Department of Neonatology, Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, China;Department of Neonatology, Nantong Maternity and Child Health Care Hospital, Nantong, China;Department of Neonatology, Northern Jiangsu People's Hospital, Yangzhou, China;Department of Pediatrics, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian, China;

关键词: enteral nutrition;    parenteral nutrition;    premature [MeSH];    growth;    first 28 days of life;   

DOI  :  10.3389/fped.2022.775667

来源: DOAJ

【 摘 要 】

BackgroundNutrition practices for preterm infants during the first few weeks of life can be divided into three phases: the parenteral nutrition (PN), enteral nutrition (EN), and transition (TN) phases; the TN phase includes both PN and EN. Our purpose was to analyze nutrition practices for very preterm infants during the TN phase and their association with the infants' growth during the first 28 days of life.MethodsData from 268 very preterm infants <32 weeks old from six neonatal intensive care units were analyzed retrospectively. The TN phase was defined as enteral feedings of 30-120 ml/kg/d. Postnatal growth failure (PGF) was defined as a 28-day growth velocity <15 g/kg/d. Differences in protein and energy intake between the PGF and non-PGF groups during the TN phase were calculated, and risk factors for PGF were identified using multivariate regression analysis.ResultsThe total protein (parenteral + enteral) intake during the TN was 3.16 (2.89, 3.47) g/kg/d, which gradually decreased as the enteral feeding volume increased in the TN phase. The total energy (parenteral + enteral) intake during the TN phase was 115.72 (106.98, 122.60) kcal/kg/d. The PGF group had a lower total protein intake (parenteral + enteral) than the non-PGF group had [3.09 (2.85, 3.38) g/kg/d vs. 3.27 (3.06, 3.57) g/kg/d, P = 0.007, respectively]. No significant difference was found in energy intake during the TN phase. The variables associated with PGF included a lower total protein (parenteral + enteral) intake, a smaller day of age at the end of the TN phase, and a higher birth weight z-score.ConclusionIncreasing the total protein intake (parenteral + enteral) during the TN could reduce the incidence of PGF.

【 授权许可】

Unknown