Oxidative Stress as Cause, Consequence, or Biomarker of Altered Female Reproduction and Development in the Space Environment

International Journal of Molecular Sciences

JeffreyR. Alberts¹  AprilE. Ronca²  JonG. Steller³ 

[1] Gynecology, University of Colorado School of Medicine, Aurora, CO 80249, USA;;Department of Psychological &;Division of Maternal Fetal Medicine, Department of Obstetrics &

关键词: oxidative stress;    cosmic radiation;    microgravity;    hind-limb unloading;    spaceflight;    reproduction;    female;    pregnancy;   

DOI  :  10.3390/ijms19123729

来源: DOAJ

【 摘 要 】

Oxidative stress has been implicated in the pathophysiology of numerous terrestrial disease processes and associated with morbidity following spaceflight. Furthermore, oxidative stress has long been considered a causative agent in adverse reproductive outcomes. The purpose of this review is to summarize the pathogenesis of oxidative stress caused by cosmic radiation and microgravity, review the relationship between oxidative stress and reproductive outcomes in females, and explore what role spaceflight-induced oxidative damage may have on female reproductive and developmental outcomes.

【 授权许可】

Unknown