Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients

Anais da Academia Brasileira de Ciências

关键词: Continuous flow;    natural products;    APIs;    synthesis;   

DOI  :  10.1590/0001-3765201820170778

来源: DOAJ

【 摘 要 】

ABSTRACT We present a comprehensive review of the advent and impact of continuous flow chemistry with regard to the synthesis of natural products and drugs, important pharmaceutical products and definitely responsible for a revolution in modern healthcare. We detail the beginnings of modern drugs and the large scale batch mode of production, both chemical and microbiological. The introduction of modern continuous flow chemistry is then presented, both as a technological tool for enabling organic chemistry, and as a fundamental research endeavor. This part details the syntheses of bioactive natural products and commercial drugs.

【 授权许可】

Unknown