Voltage and spike timing interact in STDP - a unified model

Frontiers in Synaptic Neuroscience

Wulfram Gerstner¹  Claudia Clopath² 

[1] Laboratory of Computational Neuroscience,Center for Neuroprosthetics,Ecole Polytechnique Fédérale de Lausanne (EPFL);Université Paris Descartes;

关键词: LTP;    STDP;    synaptic plasticity;    LTD;    Model;    computational neuroscience;   

DOI  :  10.3389/fnsyn.2010.00025

来源: DOAJ

【 摘 要 】

A phenomenological model of synaptic plasticity is able to account for a large body of experimental data on Spike-Timing Dependent Plasticity. The basic ingredient of the model is the correlation of presynaptic spike arrival with postsynaptic voltage. The local membrane voltage is used twice: a first term account for the instantaneous voltage and the second one on a low-pass filtered voltage trace. Spike-Timing effects emerge as a special case. We hypothesize that the voltage dependence canexplain differential effects of STDP in dendrites, since the amplitude of time course of backpropagating action potentials or dendritic spike influences the plasticity results in the model. The dendritic effects are simulated by variable choices of voltage time course at the site of the synapse, i.e., without an explicit model of the spatial structure of the neuron.

【 授权许可】

Unknown