The Dark Side of the Force: When the Immune System Is the Fuel of Tumor Onset

International Journal of Molecular Sciences

Silvia Balinzo¹  Elisabeth Digifico¹  Cristina Belgiovine¹ 

[1] Humanitas Clinical and Research Center—IRCCS, Via Manzoni 56, 20089 Rozzano (MI), Italy;

关键词: chronic inflammation;    tumor onset;    cancer-related inflammation;   

DOI  :  10.3390/ijms22031224

来源: DOAJ

【 摘 要 】

Nowadays, it is well accepted that inflammation is a critical player in cancer, being, in most cases, the main character of the process. Different types of tumor arise from sites of infection or chronic inflammation. This non-resolving inflammation is responsible for tumor development at different levels: it promotes tumor initiation, as well as tumor progression, stimulating both tumor growth and metastasis. Environmental factors, lifestyle and infections are the three main triggers of chronic immune activation that promote or increase the risk of many different cancers. In this review, we focus our attention on tumor onset; in particular, we summarize the knowledge about the cause and the mechanisms behind the inflammation-driven cancer development.

【 授权许可】

Unknown