Genome evolution in yeast reveals connections between rare mutations in human cancers

Microbial Cell

Xinchen Teng¹  J. Marie Hardwick² 

[1] College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu Province 215123, PRChina.;W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205 USA.;

关键词: yeast knockouts;    genome evolution;    secondary mutations;    cancer progression;   

DOI  :  10.15698/mic2014.06.153

来源: DOAJ

【 摘 要 】

Cancer cells are riddled with mutations. Less than one percent of these are thought to be mutations that drive cancer phenotypes. However, a recent study conducted on the yeast knockout collections by Teng et al. [Mol. Cell (2013) 52: 485–494] provides hard evidence that single gene deletions/mutations in most non-essential genes can drive the selection for cancer-like mutations.

【 授权许可】

Unknown