Therapeutic application of chick early amniotic fluid: effective rescue of acute myocardial ischemic injury by intravenous administration

Cell Regeneration

Yan Luo¹  Lihong Zhang¹  Xiang Gao¹  Tao Sun²  Jia Chen³  Borui Li³  Wenrui Sun³  Mengyuan Cai³  Yuting Zhang³  Xinyan Zhou³  Fuyin Zhu⁴  Ning Sun⁵  Baiping Cui⁵  Yufan Zheng⁵  Jiayi Xu⁶  Jin Qian⁶  Keejong Chang⁶ 

[1] Department of Biochemistry and Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine;Department of Cardiology, Huashan Hospital, Fudan University;Department of Physiology and Pathophysiology, State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences, Fudan University;Shanghai Mincal Medical Research Co. Ltd., Large Animal Research Center;Wuxi School of Medicine, Jiangnan University;Zhejiang Hygeian Cells BioMedical Co. Ltd;

关键词: Myocardial ischemic injury;    Chick early amniotic fluid;    Heart;    Yap;   

DOI  :  10.1186/s13619-022-00110-1

来源: DOAJ

【 摘 要 】

Abstract Myocardial regeneration has been considered a promising option for the treatment of adult myocardial injuries. Previously, a chick early amniotic fluid (ceAF) preparation was shown to contain growth-related factors that promoted embryonic growth and cellular proliferation, though the nature of the components within ceAF were not fully defined. Here we tested whether this ceAF preparation is similarly effective in the promotion of myocardial regeneration, which could provide an alternative therapeutic for intervening myocardial injury. In this study, a myocardial ischemic injury model was established in adult mice and pigs by multiple research entities, and we were able to show that ceAF can efficiently rescue damaged cardiac tissues and markedly improve cardiac function in both experimental models through intravenous administration. ceAF administration increased cell proliferation and improved angiogenesis, likely via down-regulation of Hippo-YAP signaling. Our data suggest that ceAF administration can effectively rescue ischemic heart injury, providing the key functional information for the further development of ceAF for use in attenuating myocardial injury.

【 授权许可】

Unknown