Uncovering the Invisible: Mono-ADP-ribosylation Moved into the Spotlight

Cells

MichaelO. Hottiger¹  Ann-Katrin Hopp¹ 

[1] Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, 8057 Zurich, Switzerland;

关键词: NAD;    NADH;    ADP-ribose;    ADP-ribosylation;    MARylation;    PARylation;   

DOI  :  10.3390/cells10030680

来源: DOAJ

【 摘 要 】

Adenosine diphosphate (ADP)-ribosylation is a nicotinamide adenine dinucleotide (NAD⁺)-dependent post-translational modification that is found on proteins as well as on nucleic acids. While ARTD1/PARP1-mediated poly-ADP-ribosylation has extensively been studied in the past 60 years, comparably little is known about the physiological function of mono-ADP-ribosylation and the enzymes involved in its turnover. Promising technological advances have enabled the development of innovative tools to detect NAD⁺ and NAD⁺/NADH (H for hydrogen) ratios as well as ADP-ribosylation. These tools have significantly enhanced our current understanding of how intracellular NAD dynamics contribute to the regulation of ADP-ribosylation as well as to how mono-ADP-ribosylation integrates into various cellular processes. Here, we discuss the recent technological advances, as well as associated new biological findings and concepts.

【 授权许可】

Unknown