Persistent activity in a recurrent circuit underlies courtship memory in Drosophila

eLife

Krystyna Keleman¹  Barry J Dickson²  Ugur Dag²  Xiaoliang Zhao²  Daniela Lenek³ 

[1] Queensland Brain Institute, University of Queensland, St Lucia, Australia;Janelia Research Campus, Ashburn, United States;Research Institute of Molecular Pathology, Vienna, Austria;

关键词: memory;    Drosophila;    mushroom body;    recurrent circuit;    persistent activity;    synaptic plasticity;   

DOI  :  10.7554/eLife.31425

来源: DOAJ

【 摘 要 】

Recurrent connections are thought to be a common feature of the neural circuits that encode memories, but how memories are laid down in such circuits is not fully understood. Here we present evidence that courtship memory in Drosophila relies on the recurrent circuit between mushroom body gamma (MBγ), M6 output, and aSP13 dopaminergic neurons. We demonstrate persistent neuronal activity of aSP13 neurons and show that it transiently potentiates synaptic transmission from MBγ>M6 neurons. M6 neurons in turn provide input to aSP13 neurons, prolonging potentiation of MBγ>M6 synapses over time periods that match short-term memory. These data support a model in which persistent aSP13 activity within a recurrent circuit lays the foundation for a short-term memory.

【 授权许可】

Unknown