期刊论文详细信息
Frontiers in Oncology
A comparison of three Deformable Image Registration Algorithms in 4DCT using conventional contour based methods and voxel-by-voxel comparison methods.
Mirek eFatyga1  Gary eChristensen2  Nesrin eDogan3  Krishni eWijesooriya4  Jeffrey eWilliamson5  Elizabeth eWeiss5  William eLehman5  William eSleeman5  Baoshe eZhang5 
[1] Mayo Clinic AZ;University of Iowa;University of Miami;University of Virginia Health Systems;Virginia Commonwealth University;
关键词: medical imaging;    Deformable Image Registration;    Deformable Dose Addition;    adiation oncology;    4DCT;   
DOI  :  10.3389/fonc.2015.00017
来源: DOAJ
【 摘 要 】

Background: Commonly used methods of assessing the accuracy of Deformable Image Registration (DIR) rely on image segmentation or landmark selection. These methods are very labor intensive and thus limited to relatively small number of image pairs. The direct voxel-by-voxel comparison can be automated to examine fluctuations in DIR quality on a long series of image pairs.Methods:A voxel-by-voxel comparison of three DIR algorithms applied to lung patients is presented. Registrations are compared by comparing volume histograms formed both with individual DIR maps and with a voxel-by-voxel subtraction of the two maps. When two DIR maps agree one concludes that both maps are interchangeable in treatment planning applications, though one cannot conclude that either one agrees with the ground truth. If two DIR maps significantly disagree one concludes that at least one of the maps deviates from the ground truth.We use the method to compare three DIR algorithms applied to peak inhale-peak exhale registrations of 4DFBCT data obtained from thirteen patients. Results: All three algorithms appear to be nearly equivalent when compared using DICE similarity coefficients. A comparison based on Jacobian Volume Histograms shows that all three algorithms measure changes in total volume of the lungs with reasonable accuracy, but show large differences in the variance of Jacobian distribution on all contoured structures. Analysis of voxel-by-voxel subtraction of DIR maps shows that the three algorithms differ to a degree which is sufficient to create a potential for dosimetric discrepancy during dose accumulation.Conclusions: DIR algorithms can perform well in some clinical applications, while potentially fail in others. These algorithms are best treated as potentially useful approximations of tissue deformation that need to be separately validated for every intended clinical application.

【 授权许可】

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