The Association of Formula Protein Content and Growth in Early Infancy: A Systematic Review and Meta-Analysis

Nutrients

Wei Zhang¹  Kaifeng Li¹  Qiqi Ren¹  Han Sun¹  Shilong Jiang¹  Chengdong Zheng¹  Hanxu Shi²  Wanyun Ye²  Ying Lyu²  Yajun Xu²  Yalin Zhou² 

[1] Innovation Center, Nutrition and Metabolism Research Division, Heilongjiang Feihe Dairy Co., Ltd., C-16, 10A Jiuxianqiao Rd., Chaoyang, Beijing 100015, China;PKUHSC-China Feihe Joint Research Institute of Nutrition and Healthy Lifespan Development, Xueyuan Road 38, Haidian, Beijing 100083, China;

关键词: infant formula;    protein/energy ratio;    breastfed;    weight gain;    height gain;   

DOI  :  10.3390/nu14112255

来源: DOAJ

【 摘 要 】

This systematic review aimed to examine differences in growth outcomes between breastfed infants and infants fed with formula with different protein/energy ratios during the first six months of life. We conducted a systematic review in the PubMed, Web of Science, and Springer databases. Twenty clinical trials qualified for inclusion. We extracted data about the growth outcomes of infants who were exclusive breastfed or exclusively infant formula fed in the first six months and used a meta-analysis to pool the finding data. We categorized study formulas into four groups according to their protein content: <1.8, 1.8–2.0, 2.1–2.2, and >2.2 g/100 kcal. In the first month of life, growth was not different between formula- and breastfed infants. During 2–3 months of life, growth was faster in infants who consumed formulas with protein contents higher than 2.0 g/100 kcal. After 3 months, formula-fed infants grew faster than breastfed infants. Our meta-analysis indicated that the growth outcomes of infants fed with infant formula with a relatively low protein/energy ratios, compared with that a relatively high protein/energy ratio, were close to those of breastfed infants.

【 授权许可】

Unknown