Prognostic and clinicopathological significance of ubiquitin-specific protease 22 overexpression in cancers: evidence from a meta-analysis

OncoTargets and Therapy

关键词: Ubiquitin-specific protease 22;    Cancer;    Survival;    Prognosis;    Meta-analysis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Ning Ao,1 Liang Wang,2 Yuqin Liu31Department of Pathology, Beijing Tiantan Hospital, Capital Medical University, 2Department of Pathology, Chinese PLA General Hospital, 3Department of Pathology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Tsinghua University, Beijing, People’s Republic of ChinaPurpose: This meta-analysis study aimed to reveal the prognostic relevance of ubiquitin-specific protease 22 (USP22) expression in patients with cancers. Methods: PubMed, Embase, and the Cochrane Library electronic databases were searched for relevant studies published up to April 2017. The prognostic value of USP22 expression was evaluated by hazard ratio with 95% confidence intervals (CIs). Relative risk (RR) with 95% CIs assessed the effects of USP22 expression on clinicopathological parameters. A total of 16 studies of 2,233 Chinese patients were included in the final meta-analysis. Results: A significant association was found between USP22 overexpression and survival in patients with cancers. The pooled RR indicated that USP22 overexpression was related to histological grade, advanced tumor–node–metastasis stage, positive lymph node metastasis, and distant metastasis. Conclusion: This meta-analysis demonstrated that USP22 could be a novel biomarker for predicting prognosis in patients with cancers in the Chinese population.Keywords: ubiquitin-specific protease 22, cancer, survival, prognosis, meta-analysis

【 授权许可】

Unknown