Near-Complete Remission of Glioblastoma in a Patient Treated with an Allogenic Dendritic Cell-Based Vaccine: The Role of Tumor-Specific CD4+T-Cell Cytokine Secretion Pattern in Predicting Response and Recurrence

International Journal of Molecular Sciences

Nadia E. Chauca-Torres¹  José A. M. Barbuto¹  Sarah F. Teixeira¹  Patricia C. Bergami-Santos¹  Carla S. Fogolin¹  Gabriela C. M. Evangelista¹  Nataly Peres¹  Jaqueline V. de Oliveira¹  Elizabeth A. Flatow¹  Mariana P. Pinho¹  Venâncio Alves²  Analía Arévalo³  Guilherme A. Lepski³  Roberta Rehder⁴ 

[1] Department of Immunology, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo 05508-000, Brazil;Department of Pathology, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 01246-903, Brazil;Hospital das Clínicas HCFMUSP, LIM26, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-000, Brazil;Hospital do Coracao, Hcor, Sao Paulo 04003-905, Brazil;

关键词: glioblastoma;    immunotherapy;    dendritic cells;    CD4+ T cells;    vaccine;    cancer treatment;   

DOI  :  10.3390/ijms23105396

来源: DOAJ

【 摘 要 】

Immunotherapy has brought hope to the fight against glioblastoma, but its efficacy remains unclear. We present the case of CST, a 25-year-old female patient with a large right-hemisphere glioblastoma treated with a dendritic–tumor cell fusion vaccine. CST showed a near-complete tumor response, with a marked improvement in her functional status and simultaneous increases in tumor-specific CD8+ and CD4+ T cells. Two months before recurrence, the frequency of tumor-specific T cells decreased, while that of IL-17 and CD4+ T cells increased. CST passed away 15 months after enrollment. In this illustrative case, the tumor-specific CD4+ T-cell numbers and phenotype behaved as treatment efficacy biomarkers, highlighting the key role of the latter in glioblastoma immunotherapy.

【 授权许可】

Unknown