Theta-modulation drives the emergence of connectivity patterns underlying replay in a network model of place cells

eLife

Yingxue Wang¹  Bernat Rovira²  Alex Roxin³  Panagiota Theodoni³ 

[1] NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai, China;New York University Shanghai, Shanghai, China;Centre de Recerca Matemàtica, Bellaterra, Spain;

关键词: hippocampus;    plasticity;    place cells;    theta oscillation;    replay;    network model;   

DOI  :  10.7554/eLife.37388

来源: DOAJ

【 摘 要 】

Place cells of the rodent hippocampus fire action potentials when the animal traverses a particular spatial location in any environment. Therefore for any given trajectory one observes a repeatable sequence of place cell activations. When the animal is quiescent or sleeping, one can observe similar sequences of activation known as replay, which underlie the process of memory consolidation. However, it remains unclear how replay is generated. Here we show how a temporally asymmetric plasticity rule during spatial exploration gives rise to spontaneous replay in a model network by shaping the recurrent connectivity to reflect the topology of the learned environment. Crucially, the rate of this encoding is strongly modulated by ongoing rhythms. Oscillations in the theta range optimize learning by generating repeated pre-post pairings on a time-scale commensurate with the window for plasticity, while lower and higher frequencies generate learning rates which are lower by orders of magnitude.

【 授权许可】

Unknown