Smaller left anterior cingulate cortex in non-bipolar relatives of patients with bipolar disorder

Brazilian Journal of Psychiatry

关键词: Bipolar disorder;    cingulate cortex;    magnetic resonance imaging;    endophenotypes;   

DOI  :  10.1590/1516-4446-2018-0051

来源: DOAJ

【 摘 要 】

Objective: Bipolar disorder (BD) is highly heritable. The present study aimed at identifying brain morphometric features that could represent markers of BD vulnerability in non-bipolar relatives of bipolar patients.Methods: In the present study, structural magnetic resonance imaging brain scans were acquired from a total of 93 subjects, including 31 patients with BD, 31 non-bipolar relatives of BD patients, and 31 healthy controls. Volumetric measurements of the anterior cingulate cortex (ACC), lateral ventricles, amygdala, and hippocampus were completed using the automated software FreeSurfer.Results: Analysis of covariance (with age, gender, and intracranial volume as covariates) indicated smaller left ACC volumes in unaffected relatives as compared to healthy controls and BD patients (p = 0.004 and p = 0.037, respectively). No additional statistically significant differences were detected for other brain structures.Conclusion: Our findings suggest smaller left ACC volume as a viable biomarker candidate for BD.

【 授权许可】

Unknown