GH/IGF-1 Abnormalities and Muscle Impairment: From Basic Research to Clinical Practice

International Journal of Molecular Sciences

Betina Biagetti¹  Rafael Simó¹ 

[1] Diabetes and Metabolism Research Unit, Vall d’Hebron Research Institute and CIBERDEM (ISCIII), Universidad Autónoma de Barcelona, 08193 Bellaterra, Spain;

关键词: acromegaly;    myopathy;    review;    growth hormone;    IGF-1;   

DOI  :  10.3390/ijms22010415

来源: DOAJ

【 摘 要 】

The impairment of skeletal muscle function is one of the most debilitating least understood co-morbidity that accompanies acromegaly (ACRO). Despite being one of the major determinants of these patients’ poor quality of life, there is limited evidence related to the underlying mechanisms and treatment options. Although growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels are associated, albeit not indisputable, with the presence and severity of ACRO myopathies the precise effects attributed to increased GH or IGF-1 levels are still unclear. Yet, cell lines and animal models can help us bridge these gaps. This review aims to describe the evidence regarding the role of GH and IGF-1 in muscle anabolism, from the basic to the clinical setting with special emphasis on ACRO. We also pinpoint future perspectives and research lines that should be considered for improving our knowledge in the field.

【 授权许可】

Unknown