Preclinical In Vivo Modeling of Pediatric Sarcoma—Promises and Limitations

Journal of Clinical Medicine

FelixK. F. Kommoss¹  Ana Banito¹  Roland Imle¹ 

[1] Hopp Children’s Cancer Center, Heidelberg (KiTZ), 69120 Heidelberg, Germany;

关键词: pediatric sarcoma;    animal models;    GEMMs;    PDXs;    preclinical testing;   

DOI  :  10.3390/jcm10081578

来源: DOAJ

【 摘 要 】

Pediatric sarcomas are an extremely heterogeneous group of genetically distinct diseases. Despite the increasing knowledge on their molecular makeup in recent years, true therapeutic advancements are largely lacking and prognosis often remains dim, particularly for relapsed and metastasized patients. Since this is largely due to the lack of suitable model systems as a prerequisite to develop and assess novel therapeutics, we here review the available approaches to model sarcoma in vivo. We focused on genetically engineered and patient-derived mouse models, compared strengths and weaknesses, and finally explored possibilities and limitations to utilize these models to advance both biological understanding as well as clinical diagnosis and therapy.

【 授权许可】

Unknown