Selenium Catalyzed Oxidation of Aldehydes: Green Synthesis of Carboxylic Acids and Esters

Molecules

Caterina Tidei¹  Luana Bagnoli¹  Luca Sancineto¹  Francesca Marini¹  Claudio Santi¹  Eder J. Lenardão² 

[1] Group of Catalysis and Organic Green Chemistry, Department of Pharmaceutical Sciences,University of Perugia, Via del Liceo 1, Perugia 06100, Italy;Laboratório de Síntese Orgânica Limpa (LASOL), Centro de Ciências Químicas,Farmacêuticas e de Alimentos (CCQFA), Universidade Federal de Pelotas (UFPel), P.O. Box 354, Pelotas 96010-900, Brazil;

关键词: aldehydes;    oxidation;    selenium;    catalysis;    carboxylic acids;    esters;    hydrogen peroxide;    green chemistry;   

DOI  :  10.3390/molecules200610496

来源: DOAJ

【 摘 要 】

The stoichiometric use of hydrogen peroxide in the presence of a selenium-containing catalyst in water is here reported as a new ecofriendly protocol for the synthesis of variously functionalized carboxylic acids and esters. The method affords the desired products in good to excellent yields under very mild conditions starting directly from commercially available aldehydes. Using benzaldehyde as a prototype the gram scale synthesis of benzoic acid is described, in which the aqueous medium and the catalyst could be recycled at last five times while achieving an 87% overall yield.

【 授权许可】

Unknown