Solid Dispersion of Resveratrol Supported on Magnesium DiHydroxide (Resv@MDH) Microparticles Improves Oral Bioavailability

Nutrients

RossanaGiulietta Iannitti¹  Maria Bastianini¹  Michela Codini²  Gabriele Brecchia³  Lorenzo Monarca³  Laura Menchetti³  Bernard Fioretti⁴  Cataldo Arcuri⁵  Loretta Mancinelli⁵  Roberto Spogli⁶  Francesco Ragonese⁶  Irina Nakashidze⁷  Federica Bastioli⁸ 

[1] Tefarm, Spin-Off Un. of University of Perugia, Via Dell’Acciaio 9, Ponte Felcino, 06134 Perugia, Italy;Department of Biology, Faculty of Natural Science and Health Care, Batumi Shota Rustaveli State University, 6010 Batumi, Georgia;Department of Chemistry, Biology and Biotechnologies, University of Perugia, Via Elce di Sotto 8, 06123 Perugia, Italy;Department of Pharmaceutical Sciences, University of Perugia, Via A. Fabretti 48, 06123 Perugia, Italy;Department of Veterinary Science, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy;;Prolabin &R Farmaceutici S.p.A Bastia Umbra, 08063 Perugia Italy;;S&

关键词: resveratrol;    magnesium dihydroxide;    solubility;    bioavailability;    dissolution rate;    microparticles;   

DOI  :  10.3390/nu10121925

来源: DOAJ

【 摘 要 】

Resveratrol, because of its low solubility in water and its high membrane permeability, is collocated in the second class of the biopharmaceutical classification system, with limited bioavailability due to its dissolution rate. Solid dispersion of resveratrol supported on Magnesium DiHydroxide (Resv@MDH) was evaluated to improve solubility and increase bioavailability of resveratrol. Fluorimetric microscopy analysis displays three types of microparticles with similar size: Type 1 that emitted preferably fluorescence at 445 nm with bandwidth of 50 nm, type 2 that emitted preferably fluorescence at 605 nm with bandwidth of 70 nm and type 3 that is non-fluorescent. Micronized pure resveratrol displays only microparticles type 1 whereas type 3 are associated to pure magnesium dihydroxide. Dissolution test in simulated gastric environment resveratrol derived from Resv@MDH in comparison to resveratrol alone displayed better solubility. A 3-fold increase of resveratrol bioavailability was observed after oral administration of 50 mg/kg of resveratrol from Resv@MDH in rabbits. We hypothesize that type 2 microparticles represent magnesium dihydroxide microparticles with a resveratrol shell and that they are responsible for the improved resveratrol solubility and bioavailability of Resv@MDH.

【 授权许可】

Unknown