Variants of the Aggression-Related RBFOX1 Gene in a Population Representative Birth Cohort Study: Aggressiveness, Personality, and Alcohol Use Disorder

Frontiers in Psychiatry

Andreas Reif¹  Barbara Franke⁴  Stephen V. Faraone⁵  Mariliis Vaht⁶  Margus Kanarik⁶  Jaanus Harro⁶  Kariina Laas⁶  Noèlia Fernàndez-Castillo⁸  Bru Cormand⁸  Liina-Mai Tooding⁹  Triin Kurrikoff⁹  Toomas Veidebaum^1,10 

[1] 0Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt Goethe University, Frankfurt am Main, Germany;Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain;Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain;Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Nijmegen, Netherlands;Departments of Psychiatry and of Neuroscience and Physiology, The State University of New York Upstate Medical University, Syracuse, NY, United States;Division of Neuropsychopharmacology, Department of Psychology, Estonian Center of Behavioral and Health Sciences, University of Tartu, Tartu, Estonia;Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain;Institut de Recerca Sant Joan de Déu (IR-SJD), Esplugues de Llobregat, Spain;Institute of Social Studies, University of Tartu, Tartu, Estonia;National Institute for Health Development, Estonian Center of Behavioral and Health Sciences, Tallinn, Estonia;

关键词: RBFOX1;    A2BP1;    aggressiveness;    neuroticism;    extraversion;    alcohol use disorder;   

DOI  :  10.3389/fpsyt.2020.501847

来源: DOAJ

【 摘 要 】

Background: Recently, RBFOX1, a gene encoding an RNA binding protein, has consistently been associated with aggressive and antisocial behavior. Several loci in the gene have been nominally associated with aggression in genome-wide association studies, the risk alleles being more frequent in the general population. We have hence examined the association of four RBFOX1 single nucleotide polymorphisms, previously found related to aggressive traits, with aggressiveness, personality, and alcohol use disorder in birth cohort representative samples.Methods: We used both birth cohorts of the Estonian Children Personality Behavior and Health Study (ECPBHS; original n = 1,238). Aggressiveness was assessed using the Buss–Perry Aggression Questionnaire and the Lifetime History of Aggressiveness structured interview at age 25 (younger cohort) or 33 (older cohort). Big Five personality at age 25 was measured with self-reports and the lifetime occurrence of alcohol use disorder assessed with the MINI interview. RBFOX1 polymorphisms rs809682, rs8062784, rs12921846, and rs6500744 were genotyped in all participants. Given the restricted size of the sample, correction for multiple comparisons was not applied.Results: Aggressiveness was not significantly associated with the RBFOX1 genotype. RBFOX1 rs8062784 was associated with neuroticism and rs809682 with extraversion. Two out of four analyzed RBFOX1 variants, rs8062784 and rs12921846, were associated with the occurrence of alcohol use disorder.Conclusions: In the birth cohort representative sample of the ECPBHS, no association of RBFOX1 with aggressiveness was found, but RBFOX1 variants affected basic personality traits and the prevalence of alcohol use disorder. Future studies on RBFOX1 should consider the moderating role of personality and alcohol use patterns in aggressiveness.

【 授权许可】

Unknown