A Distinct Cytokine Profile and Stromal Vascular Fraction Metabolic Status without Significant Changes in the Lipid Composition Characterizes Lipedema

International Journal of Molecular Sciences

Stefan Wolf¹  Bong-Sung Kim¹  Epameinondas Gousopoulos¹  Lisanne Grünherz¹  Mauro Vasella¹  Pietro Giovanoli¹  Nicole Lindenblatt¹  JeremyW. Deuel²  Gunther Felmerer³  Maija Hollmén⁴ 

[1] Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland;Division of Internal Medicine, University Hospital of Zurich, 8091 Zurich, Switzerland;Division of Plastic Surgery, Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Göttingen, Georg-August-University, 37099 Göttingen, Germany;MediCity Research Laboratory, University of Turku, 20520 Turku, Finland;

关键词: lipedema;    adipose tissue;    lipidomics;    mitochondrial respiration;   

DOI  :  10.3390/ijms22073313

来源: DOAJ

【 摘 要 】

Lipedema is an adipose tissue disorder characterized by the disproportionate increase of subcutaneous fat tissue in the lower and/or upper extremities. The underlying pathomechanism remains unclear and no molecular biomarkers to distinguish the disease exist, leading to a large number of undiagnosed and misdiagnosed patients. To unravel the distinct molecular characteristic of lipedema we performed lipidomic analysis of the adipose tissue and serum of lipedema versus anatomically- and body mass index (BMI)-matched control patients. Both tissue groups showed no significant changes regarding lipid composition. As hyperplastic adipose tissue represents low-grade inflammation, the potential systemic effects on circulating cytokines were evaluated in lipedema and control patients using the Multiplex immunoassay system. Interestingly, increased systemic levels of interleukin 11 (p = 0.03), interleukin 28A (p = 0.04) and interleukin 29 (p = 0.04) were observed. As cytokines can influence metabolic activity, the metabolic phenotype of the stromal vascular fraction was examined, revealing significantly increased mitochondrial respiration in lipedema. In conclusion, despite sharing a comparable lipid profile with healthy adipose tissue, lipedema is characterized by a distinct systemic cytokine profile and metabolic activity of the stromal vascular fraction.

【 授权许可】

Unknown