Deoxynivalenol (Vomitoxin)-Induced Anorexia Is Induced by the Release of Intestinal Hormones in Mice

Toxins

Eugenie Nepovimova¹  Kamil Kuca¹  Jianming Yue²  Xiuge Gao²  Dawei Guo²  Wenda Wu²  Jiacai Wang³ 

[1] Department of Chemistry, Faculty of Science, University of Hradec Králové, Rokitanského 62, 500 03 Hradec Kralove, Czech Republic;MOE Joint International Research Laboratory of Animal Health and Food Safety, Engineering Center of Innovative Veterinary Drugs, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China;Shandong Vocational Animal Science and Veterinary College, 88 Shengli East Street, Weifang 261061, China;

关键词: mycotoxin;    trichothecene;    deoxynivalenol;    intestinal hormones;    anorexia;   

DOI  :  10.3390/toxins13080512

来源: DOAJ

【 摘 要 】

Deoxynivalenol (DON), also known as vomitoxin, is a mycotoxin that can cause antifeeding and vomiting in animals. However, the mechanism of DON inducing anorexia is complicated. Studies have shown that intestinal hormones play a significant part in the anorexia caused by DON. We adopted the “modeling of acute antifeeding in mice” as the basic experimental model, and used two methods of gavage and intraperitoneal injection to explore the effect of intestinal hormones on the antifeedant response induced by DON in mice. We found that 1 and 2.5 mg/kg·bw of DON can acutely induce anorexia and increase the plasma intestinal hormones CCK, PYY, GIP, and GLP-1 in mice within 3 h. Direct injection of exogenous intestinal hormones CCK, PYY, GIP, and GLP-1 can trigger anorexia behavior in mice. Furthermore, the PYY receptor antagonist JNJ-31020028, GLP-1 receptor antagonist Exendin(9-39), CCK receptor antagonist Proglumide, GIP receptor antagonist GIP(3-30)NH₂ attenuated both intestinal hormone and DON-induced anorectic responses. These results indicate that intestinal hormones play a critical role in the anorexia response induced by DON.

【 授权许可】

Unknown