Avanços, propriedades e aplicações de dispersões sólidas no desenvolvimento de formas farmacêuticas sólidas

Revista de Ciências Farmacêuticas Básica e Aplicada

Larissa Araújo Rolim¹  Geisiane Maria Alves Presmich¹  Magaly Andreza Marques de Lyra¹  Lariza Darlene Santos Alves¹  Pedro José Rolim-Neto¹ 

[1] Laboratório de Tecnologia dos Medicamentos, Departamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco, UFPE, Recife, PE, Brasil.;

关键词: Solid dispersion;    Multicomponent systems;    Hydrophilic carriers;   

DOI  :  

来源: DOAJ

【 摘 要 】

Amorphous solid dispersions feature widely in strategies to improve the bioavailability of poorly water-soluble compounds. However, there are few reports of this technique being used in finished products, demonstrating a need for in depth knowledge of the main and most recent production techniques used on the laboratory and industrial scale, as well as of the main physicochemical characteristics of the most widely used hydrophilic polymers, listing their advantages and disadvantages and potential applications. In this review, it is intended to discuss the recent advances regarding solid dispersions and their use in multicomponent systems.

【 授权许可】

Unknown