Dynamic Changes in the Systemic Inflammation Response Index Predict the Outcome of Resectable Gastric Cancer Patients

Frontiers in Oncology

Haijue Ge¹  Zhilong Miao²  Shoupeng Shao³  Congsong Dong⁴  Zhenhua Liu⁵  Hongtai Shi⁶ 

[1] Department of Gastroenterology, The Third People’s Hospital of Yancheng, Yancheng, China;Department of General Surgery, The Third People’s Hospital of Yancheng, Yancheng, China;Department of Oncology, The Third People’s Hospital of Yancheng, Yancheng, China;Department of Radiology, The Third People’s Hospital of Yancheng, Yancheng, China;Department of Radiotherapy, The First People’s Hospital of Yancheng, Yancheng, China;Department of Radiotherapy, The Third People’s Hospital of Yancheng, Yancheng, China;

关键词: systemic inflammation response index;    gastric cancer;    prognosis;    neutrophil/lymphocyte ratio;    platelet/lymphocyte ratio;    monocyte/lymphocyte ratio;   

DOI  :  10.3389/fonc.2021.577043

来源: DOAJ

【 摘 要 】

The systemic inflammation response index (SIRI) has been revealed to be closely related to the prognosis of a variety of tumors. Whether the dynamic change in SIRI before and after surgery can be used to judge the prognosis of patients after radical gastrectomy has not yet been studied. In this study, the predictive ability of preoperative SIRI and changes in SIRI before and after surgery for the survival rate of gastric cancer patients was evaluated in two independent cohorts. It was found that SIRI was closely related to TNM staging. The higher the TNM stage, the higher the proportion of patients with a high SIRI. However, SIRI was not related to any other clinicopathological parameters. Kaplan-Meier survival analysis showed that a high SIRI was associated with poor prognosis in gastric cancer patients in the original cohort and in the validation cohort. SIRI, NLR, PLR, and MLR could be used to judge the prognosis of patients with operable gastric cancer. However, multivariate analysis suggested that only SIRI was an independent prognostic factor for patients with operable gastric cancer. In addition, the change in SIRI at 4 to 6 weeks after surgery compared with SIRI before surgery was closely related to the survival of gastric cancer patients. Compared with the unchanged group (absolute variation <50%), gastric cancer patients with a SIRI increase >50% had a worse OS, while patients with a SIRI decrease >50% had a better prognosis. In conclusion, SIRI can be used as a reliable index to evaluate the prognosis of patients with operable gastric cancer, and the dynamic change in SIRI before and after surgery is significantly related to the prognosis of patients with gastric cancer.

【 授权许可】

Unknown