Anti-colon cancer activity of endophytic fungal strains from Terminalia chebula Rezt

Bangladesh Journal of Pharmacology

Mohammad Shoeb¹  Nilufar Nahar¹  Paul Kong Thoo-Lin² 

[1] Department of Chemistry, University of Dhaka, Dhaka;School of Pharmacy and Life Science,The Robert Gordon University, Aberdeen;

关键词: Colon cancer;    Cytotoxicity;    Endophytic fungus;   

DOI  :  10.3329/bjp.v7i1.10507

来源: DOAJ

【 摘 要 】

Endophytic microorganisms are fungi or bacteria that live inside the healthy tissues of the host plants causing no apparent symptoms of diseases. Five endophytic fungal strains labeled as IR-1, IR-2, IR-4, IR-6 and IR-7 (identified as Penicillium thiomii) were isolated from the medicinal plant of Terminalia chebula Retz by culture and sub-culture. The ethyl acetate extract of fungal strains, IR-4, IR-6 and IR-7 inhibited the growth of CaCo-2 colon cancer cell lines in MTT assay with IC50 values of 55, 44 and 67 µg/mL, respectively.

【 授权许可】

Unknown