The effect of use simvastatin at treatment of ischemic heart disease patients of senile age

Кардиоваскулярная терапия и профилактика

A. L. Pirogov¹  V. K. Rufanova¹  E. M. Ermak¹  S. P. Sinitsyn²  E. V. Davydova² 

[1] Chelyabinsk regional clinical therapeutic hospital for veterans of wars;The Chelyabinsk state medical academy;

关键词: senile age;    ischemic heart disease;    simvastatin;   

DOI  :  

来源: DOAJ

【 摘 要 】

Aim. To study influence of simvastatin application on clinic, the laboratory and tool data, and as the remote forecast at patients with ischemic heart disease of senile age (75 years and are more senior) with clinic of chronic heart failure. Material and methods. . 60 men were included in research and women in the age of from 75 till 85 years, hearts suffering by ischemic illness with display of intimate insufficiency and divided on 2 equal groups a method of random numbers. Ill control group received standard therapy concerning ischemic heart disease and chronic heart failure, and ill groups of research, in addition to standard therapy, received simvastatin in a doze 20 mg / days. The period of supervision - 12 months. Results. On the termination of the period of supervision there was an authentic divergence of curves survivals in observably groups for the benefit of the patients accepting simvastatin; authentic improvement of function vascular endothelium, reduction of a class of a stenocardia in group of intervention is marked. Clinical results are confirmed with decrease of level СRP, TNFá. Authentic growth of level NO of plasma in group of simvastatin application was not observed, and this fact in the given research contacts additional reception or a cancellation of prolonged nitrates patients during treatment. Сonclusion. By results of the executed research positive influence simvastatin on clinic and the forecast of outcome of disease at patients of the senile age, suffering is confirmed with ischemic illness of heart. Significant growth of the by-effects limiting application simvastatin in a daily doze of 20 mg at patients to the given age group, is not marked. Research will be continued.

【 授权许可】

Unknown