Phytochemical Contents and Pharmacological Potential of Parkia speciosa Hassk. for Diabetic Vasculopathy: A Review

Antioxidants

Siti Safiah Mokhtar¹  Aida Hanum Ghulam Rasool¹  Ahmad Khusairi Azemi¹  Nur Amalina Noralidin²  Muhammad Luqman Nordin²  Kamarul Ariffin Hambali³ 

[1] Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia (Health Campus), Kota Bharu 16150, Kelantan, Malaysia;Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, Pengkalan Chepa, Kota Bharu 16100, Kelantan, Malaysia;Faculty of Earth Science, Universiti Malaysia Kelantan, Jeli 17600, Kelantan, Malaysia;

关键词: diabetes;    hypoglycemic;    antioxidant;    anti-inflammatory;    endothelial dysfunction;   

DOI  :  10.3390/antiox11020431

来源: DOAJ

【 摘 要 】

Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and is considered a major health problem in the world. It is associated with endothelial dysfunction which causes progressive vascular damage. DM is a known risk factor for atherosclerosis and cardiovascular complications such as peripheral artery disease, coronary artery disease, and stroke. Medicinal plants may act as an alternative resource or adjunctive treatment option in the treatment of diabetes and its cardiovascular complications. Parkia speciosa (Fabaceae) is a plant found abundantly in the Southeast Asian region. Its seeds, with or without pods, and roots have long been used as a traditional medicine in this region to treat hypertension and diabetes. Studies have shown its numerous beneficial pharmacological properties. Extracts of P. speciosa, particularly from its seeds and empty pods, show the presence of polyphenols. They also exhibit potent antioxidant, hypoglycemic, anti-inflammatory, and antihypertensive properties. Its hypoglycemic properties are reported to be associated with the presence of β-sitosterol, stigmasterol, and stigmat-4-en-3-one. The current review aimed to provide an overview of the current status of P. speciosa, its pharmacological potential, and its phytochemical content in attenuating diabetic vasculopathy. Glycemic status, oxidative stress, inflammation, and hyperlipidemia are known to play pivotal roles in the initiation and severity of diabetic cardiovascular diseases; thus, targeting these factors might be beneficial for preventing and/or treating diabetic vasculopathy.

【 授权许可】

Unknown