Infections caused by Clostridium difficile in cancer patients

Sibirskij Onkologičeskij Žurnal

N. V. Dmitrieva¹  I. A. Klyuchnikova¹  I. N. Petukhova¹  Z. V. Grigorievskaya¹  I. V. Tereshchenko¹  N. S. Bagirova¹ 

[1] N.N. Blokhin National Medical Research Cancer Center, Ministry of Health of the Russian Federation;

关键词: clostridium difficile;    toxins a and b clostridium difficile;    antibiotic-associated diarrhea;    cancer patient;    antibiotics;    infectious complications;    nosocomial environment;    cephalosporin;    toxins;   

DOI  :  10.21294/1814-4861-2018-17-6-92-96

来源: DOAJ

【 摘 要 】

The purpose of the study was to determine the role of antibiotics as a risk factor of Clostridium difficile-associated diarrhea in hospitalized cancer patients.Material and Methods. The study included 844 hospitalized cancer patients with diarrhea. The presence of Clostridium difficile toxins A and B in the fecal samples was determined by enzyme immunoassay.Results. Clostridium difficile toxins A and B were detected in 100 cancer patients (42 % men and 58 % women). The incidence of Clostridium difficile-associated diarrhea was higher in women than in men (р<0.02). Patients with hemoblastosis and gastrointestinal tumors were more susceptible to the development of Clostridium difficile associated diarrhea (p<0.02). The use of cephalosporin antibiotics was the main risk factor (р<0.001). In our study, 46 % of the patients took antibiotics.Conclusion. Clostridium difficile was shown to play a significant role in the development of diarrhea in cancer patients, and early detection of Clostridium difficile infection contributes to the early onset of therapy.

【 授权许可】

Unknown