Oxidative Stress in Preterm Newborns

Antioxidants

Serafina Perrone¹  Giuseppe Buonocore²  Chiara Lembo² 

[1] Department of Medicine and Surgery, Neonatology Unit, University of Parma, 43126 Parma, Italy;Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy;

关键词: oxidative stress;    free radicals;    newborn infants;    prematurity;    antioxidants;    biomarkers;   

DOI  :  10.3390/antiox10111672

来源: DOAJ

【 摘 要 】

Preterm babies are highly susceptible to oxidative stress (OS) due to an imbalance between the oxidant and antioxidant systems. The generation of free radicals (FR) induces oxidative damage to multiple body organs and systems. OS is the main factor responsible for the development of typical premature infant diseases, such as bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis, intraventricular hemorrhage, periventricular leukomalacia, kidney damage, eryptosis, and also respiratory distress syndrome and patent ductus arteriosus. Many biomarkers have been detected to early identify newborns at risk of developing a free radical-mediated disease and to investigate new antioxidant strategies. This review reports the current knowledge on OS in the preterm newborns and the newest findings concerning the use of OS biomarkers as diagnostic tools, as well as in implementing antioxidant therapeutic strategies for the prevention and treatment of these diseases and their sequelae.

【 授权许可】

Unknown