Modifying Adaptive Therapy to Enhance Competitive Suppression

Cancers

AndrewF. Read¹  Elsa Hansen¹ 

[1] Department of Biology, Pennsylvania State University, University Park, PA 16802, USA;

关键词: competition;    resistance;    treatment regimen;    adaptive therapy;   

DOI  :  10.3390/cancers12123556

来源: DOAJ

【 摘 要 】

Adaptive therapy is a promising new approach to cancer treatment. It is designed to leverage competition between drug-sensitive and drug-resistant cells in order to suppress resistance and maintain tumor control for longer. Prompted by encouraging results from a recent pilot clinical trial, we evaluate the design of this initial test of adaptive therapy and identify three simple modifications that should improve performance. These modifications are designed to increase competition and are easy to implement. Using the mathematical model that supported the recent adaptive therapy trial, we show that the suggested modifications further delay time to tumor progression and also increase the range of patients who can benefit from adaptive therapy.

【 授权许可】

Unknown