Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst

Molecules

关键词: nitro-Mannich;    ytterbium;    heterobimetallic;    asymmetric catalysis;    amide-based ligand;   

DOI  :  10.3390/molecules15031280

来源: DOAJ

【 摘 要 】

A catalytic asymmetric nitro-Mannich (aza-Henry) reaction with rare earth metal/alkali metal heterobimetallic catalysts is described. A Yb/K heterobimetallic catalyst assembled by an amide-based ligand promoted the asymmetric nitro-Mannich reaction to afford enantioenriched anti-b-nitroamines in up to 86% ee. Facile reduction of the nitro functionality allowed for efficient access to optically active 1,2-diamines.

【 授权许可】

Unknown