The relationship between vitamin D receptor gene polymorphism and deciduous tooth decay in Chinese children

BMC Oral Health

Miao Yu¹  Wen-juan Zhang²  Xue-chao Yang³  Su-juan Zeng⁴  Jian-mao Zheng⁵  Yuan-yuan Kong⁶  Qian-zhou Jiang⁶ 

[1] Department of Dongfengxi Clinic, Stomatology Hospital of Guangzhou Medical University;Department of Endodontics, Stomatology Hospital of Guangzhou Medical University;Department of Oral Digital Center, Stomatology Hospital of Guangzhou Medical University;Department of Pediatric Dentistry, Stomatology Hospital of Guangzhou Medical University;Guangdong Provincial Key Laboratory of Stomatology, Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Affiliated Stomatological Hospital, Sun Yat-sen University;Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University;

关键词: Deciduous tooth decay;    Vitamin D receptor;    Gene polymorphisms;   

DOI  :  10.1186/s12903-017-0398-x

来源: DOAJ

【 摘 要 】

Abstract Background In the present study, we explored the link between vitamin D receptor (VDR) BsmI, TaqI, ApaI and FokI gene polymorphisms with deciduous tooth decay in Chinese children. Methods Our study included 380 Chinese children aged 4–7 years, whose DNA sample was collected from the buccal mucosa. VDR gene polymorphisms was determined by PCR-RFLP. Results The adjusted logistic regression analysis demonstrated that BsmI containing the Bb genotype was linked with the increased risk of deciduous tooth decay (OR = 1.856, 95% CI = [1.184, 2.908], p = 0.007). However, VDR polymorphisms ApaI, TaqI and FokI were not associated with deciduous tooth decay (ApaI: OR = 0.839, 95% CI = [0.614, 1.145], p = 0.268; TaqI: OR = 1.150, 95% CI = [0.495, 2.672], p = 0.744; FokI: OR = 0.856, 95% CI = [0.616, 1.191], p = 0.356). Conclusions Our results showed that VDR BsmI polymorphism was associated with the risk of deciduous tooth decay in Chinese children aged 4–7 years. However, the specific mechanism remains to further verify through experiment.

【 授权许可】

Unknown