Combination of anti-PD-1 therapy and stereotactic radiosurgery for a gastric cancer patient with brain metastasis: a case report

BMC Cancer

Kanghan Lee¹  Woo Kyun Bae¹  Min-joo Ahn¹  In-Young Kim²  Kyung Hwa Lee³  Jin Woong Kim⁴ 

[1] Departments of Internal Medicine, Chonnam National University Medical School;Departments of Neurosurgery, Chonnam National University Medical School;Departments of Pathology, Chonnam National University Medical School;Departments of Radiology, Chonnam National University Medical School;

关键词: Anti-PD-1 therapy;    Stereotactic radiosurgery;    Gastric cancer;    Brain metastasis;   

DOI  :  10.1186/s12885-017-3906-0

来源: DOAJ

【 摘 要 】

Abstract Background Brain metastases from gastric cancer are difficult to treat and their prognosis is poor. Despite various possible treatments, the survival rate of such patients is still unsatisfactory; therefore, new treatment modalities or combinations of therapies need to be explored. Case presentation We herein discuss a case of a 38-year-old man initially diagnosed with a gastric cancer brain metastasis. At first, only stereotactic radiosurgery (SRS) was performed, but it was not effective. After the brain and systemic metastases progressed, SRS and anti-PD-1 therapy were administered in combination, and the brain and intra-abdominal metastatic lesions responded satisfactorily. Conclusion The combination of anti-PD-1 therapy and SRS could be effective against gastric cancer with brain metastases.

【 授权许可】

Unknown