Fibre-specific laterality of white matter in left and right language dominant people

NeuroImage

Thijs Dhollander¹  Helena Verhelst²  Guy Vingerhoets²  Robin Gerrits³ 

[1] Corresponding author: Department of Experimental Psychology, Ghent University, Henri Dunantlaan 2, 9000 Ghent, Belgium;Department of Experimental Psychology, Ghent University, Belgium;Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia;

关键词: Laterality;    Asymmetry;    Language;    Diffusion MR;    Fixel‐based analysis;    White matter;   

DOI  :  

来源: DOAJ

【 摘 要 】

Language is the most commonly described lateralised cognitive function, relying more on the left hemisphere compared to the right hemisphere in over 90% of the population. Most research examining the structure-function relationship of language lateralisation only included people showing a left language hemisphere dominance. In this work, we applied a state-of-the-art ''fixel-based'' analysis approach, allowing statistical analysis of white matter micro- and macrostructure on a fibre-specific level in a sample of participants with left and right language dominance (LLD and RLD). Both groups showed a similar extensive pattern of white matter lateralisation including a comparable leftwards lateralisation of the arcuate fasciculus, regardless of their functional language lateralisation. These results suggest that lateralisation of language functioning and the arcuate fasciculus are driven by independent biases. Finally, a significant group difference of lateralisation was detected in the forceps minor, with a leftwards lateralisation in LLD and rightwards lateralisation for the RLD group.

【 授权许可】

Unknown