A Six-Year Gynecological Follow-Up of Immunosuppressed Women with a High-Risk Human Papillomavirus Infection

International Journal of Environmental Research and Public Health

Bronisława Pietrzak¹  Miroslaw Wielgos¹  Barbara Suchonska¹  Aleksandra Wielgos²  Lidia Rudnicka²  Mariusz Sikora³ 

[1] 1st Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-115 Warsaw, Poland;Department of Dermatology, Medical University of Warsaw, 02-008 Warsaw, Poland;National Institute of Geriatrics, Rheumatology and Rehabilitation, 02-006 Warsaw, Poland;

关键词: HPV;    human papillomavirus;    immunosuppression;    transplantation;    cervical cancer;    self-sampling;   

DOI  :  10.3390/ijerph19063531

来源: DOAJ

【 摘 要 】

Immunocompromised women are at an increased risk of developing malignancies, especially those that are viral-induced, such as invasive cervical cancer caused by the human papillomavirus (HPV). The aim of the study was to describe gynecological follow-up of women undergoing chronic immunosuppressive therapy for various reasons (e.g., kidney/liver transplant, systemic lupus erythematosus), diagnosed with a high-risk HPV (hrHPV) infection based on a self-sampling test. Twenty-six hrHPV-positive women were invited to take part in a gynecological follow-up, including a visual assessment of the anogenital region, two-handed gynecological examination, and cervical cytology as well as a colposcopy and cervical biopsy when necessary. Four women declined taking part in the study. Over six years of observation, low-grade squamous intraepithelial lesions (LSIL) were detected at least once in 7/22 women (31.8%), and a cervical intraepithelial lesion 1 (CIN 1) histopathologic result was obtained five times in 3/22 women. No cases of high-grade squamous intraepithelial lesions, CIN 2/3, or invasive cervical cancers were observed. Loop electrosurgical excision procedure (LEEP) was performed in three patients. As immunocompromised women are prone to persistent hrHPV infections, they should be under strict gynecological supervision because only vigilant surveillance enables fast detection and treatment of early dysplasia and, therefore, provides a chance for the reduction of the cervical cancer burden.

【 授权许可】

Unknown